Shishido is Youko's childhood friend and a wolfman with a split personality tied to the lunar cycle. Most of the time she appears as Shirou—a rough, intimidating guy with sharp teeth—but moonlight (or even just seeing the moon's image) triggers an instant transformation into Shiho, a charismatic, bushy-tailed woman with a major perverted streak. Another glimpse of the moon flips her back. Shiho's the dominant personality and stays aware of everything that happens when Shirou's in control, which gives her a weird advantage.
Shirou's got a genuine crush on Youko and spends a lot of energy trying to figure out if Asahi knows about her secret. Shiho, on the other hand, is way more playful and openly lustful—she actually enjoys being a pervert. She loves messing with Youko, constantly pushing her to admit how she really feels about Asahi. Her father's also a wolfman, and while her mother barely appears on screen, she's only shown in silhouette and gets described as a "Charismatic Female Pervert" herself, which probably explains where Shiho gets it from.
Content compiled by AnimeList.moe from publicly available sources.