Medusa is the primary antagonist of Soul Eater and Crona's mother. She's best known for psychologically manipulating her own child into collecting souls, implanting hypnotic spells in Crona's mind to fuel their violent impulses whenever they hesitate. Her methods are ruthless—she'll infect other witches with snake bombs to force cooperation, all while keeping her soul protected enough to avoid detection.
She infiltrates Shibusen by posing as both a teacher and nurse, giving her access to student files and the perfect vantage point to identify potential kishin candidates. While undercover, she maintains a supportive facade that completely masks her true nature. Like Dr. Stein, she views people as experiments to be studied and exploited without moral restraint.
Medusa's witch magic centers on snakes—she keeps thousands inside her body and constantly chants "Nake snake cobra cobubra" as part of her spellcasting. Her entire aesthetic, from her clothes to her mannerisms, plays into the snake theme.
She faces off against Stein in a brutal fight deep within Shibusen's lowest levels, orchestrating Asura's resurrection in the process. Initially dominant, she gets careless celebrating Asura's awakening, which gives Stein the opening he needs. He cuts her in half, then drives his blade through her skull as she makes one final attack, claiming to love him before her body dissolves.
But she doesn't stay dead. A snake bearing her signature arrow markings is spotted escaping through a drainpipe—clearly her transformed. Later, she's confirmed alive after possessing a young girl named Rachel. From there, she obtains the legendary artifact BREW and orchestrates a student attack against her older sister Arachne.
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