Gracia Hughes is best known as the devoted wife of Maes Hughes and mother to Elicia. She's characterized as genuinely kind and caring—the sort of person who opens her home without hesitation. Though she doesn't appear constantly throughout the series, her presence matters; she puts Winry up when she's in Central and welcomes Sheska's frequent visits.
The manga reveals she and Hughes had already met before he shipped out to Ishval, which adds depth to their relationship beyond what the anime initially shows.
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